I got some flak for this on another forum for posting something similar, and I think the consensus was that some of these things vibrate themselves to pieces, and some of them don't. I have a problem with my feet more than my hands going to sleep.
But, I've had these issues related to excessive vibration, depsite the use of loctite:
- Couldn't use aftermarket mirrors and switched back to factory. Vibrated too much to see anything and constantly came loose.
- When I ran my old Baron's light bar the mounting threaded studs would slowly unscrew at highway speed until were all the way out.
- Had to switch to passenger floor boards because my girlfriend would say that her feet would go so numb that they would start cramping after 50 miles or so.
Mine honestly doesn't seem as bad as it used to and less things are coming loose, so I don't know.